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"An apple in a day keeps the doctor away"  is a wonderful and famous proverb about an APPLE Fruit and it is 100 percent true.
Below topic is obtained from https://www.medicalnewstoday.com as it very important to know for everyone.
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Apples Are Good For Neurological Health, Says New Research
Published Friday 20 October 2006
Adapted Media Release
For those who think that picking and eating apples this time of year is just for fun and for the great taste of America's favorite fruit, you may want to think again. Apples and apple juice may be among the best foods that anyone could add to their diet, finds a collection of recent research studies, the latest of which was presented yesterday at the Society of Neuroscience annual conference in Atlanta. Researchers G. Bureau and M. Martinoli from the University of Quebec a Trois-Rivieres, found that quercetin (one of the antioxidants found abundantly in apples) was one of two compounds that helped to reduce cellular death that is caused by oxidation and inflammation of neurons. An abstract of their presentation can be found at http://tinyurl.com/wdu4h.
This finding was previously confirmed not just by testing quercetin by itself, but by using apples as a whole food. Published in the May 2006 issue of Experimental Biology and Medicine, researcher Eric Gershwin, M.D., with the University of California, Davis Health System, discovered a way in which flavonoid-rich apples and apple juice protect cells from damage. Gershwin exposed human cells to an extract of apple mash made from different apple varieties, similar to outcomes presented today at the Society of Neuroscience meeting. The UC Davis researchers then challenged these cells by exposing them to tumor necrosis factor (TNF), a protein-like compound found in the body that usually triggers cell death and promotes inflammation via a mechanism called the ?nuclear factor kappa B pathway? (this pathway involves chemical signaling between cells). The UC Davis research revealed that apple extract protected the cells from the normally lethal effects of TNF by interfering with this pathway that would otherwise damage or kill cells in the body. Gershwin noted that the method by which apple extract protects cells is different than that reported for other flavonoid-rich foods.
Other more recent research demonstrated how apples and apple juice can help boost neurological health, specifically in the brain. The latest study from the University of Massachusetts Lowell (UML), published in the August 2006 Journal of Alzheimer's Disease, indicates that apple juice consumption may actually increase the production in the brain of the essential neurotransmitter acetylcholine, resulting in improved memory among mice who have Alzheimer's-like symptoms.
Neurotransmitters such as acetylcholine are chemicals released from nerve cells that transmit messages to other nerve cells. Such communication between nerve cells is vital for overall good health, not just in the brain. In addition to finding the improved levels of acetylcholine in their brains, ?it was surprising how the animals on the apple-enhanced diets actually did a superior job on the maze tests than those not on the apple-supplemented diet,? remarks Dr. Thomas Shea, who led the research.
Shea, who is the director of the UML Center for Cellular Neurobiology and Neurodegeneration, published yet another study in the December 2005 Journal of Alzheimer's Disease in which older mice (not mice with Alzheimer's like conditions) performed significantly better on memory tests than did animals whose diet was not enriched with apple products. Both of these studies, along with similar study published by Shea in the February 2004 issue of Journal of Nutrition, Health and Aging strongly suggests that apples must possess a unique mix of antioxidants that improve cognition and memory via inhibition of oxidation in the brain.
Both the UC Davis and UML studies were funded by unrestricted grants provided by the U.S. Apple Association and Apple Products Research and Education Council.
The U.S. Apple Association (USApple) is the national trade association representing all segments of the apple industry. Members include 36 state and regional apple associations representing the 7,500 apple growers throughout the country, as well as more than 300 individual firms involved in the apple business. USApple's mission is to provide the means for all segments of the U.S. apple industry to join in appropriate collective efforts to profitably produce and market apples and apple products.
http://www.usapple.org
8233 Old Courthouse Road
Suite 200
Vienna, VA 22182-3816
USA
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Below are the main advantages of the eating apple in daily life.
Anticipate gallstones
This is one of the medical advantages of apples that is educational. Gallstones shape when there's an excessive amount of cholesterol in your bile for it to stay as a fluid, so it cements. They are especially pervasive in the hefty. To forestall gallstones, specialists suggest an eating routine high in fiber (ahem, apples once more) to enable you to control your weight and cholesterol levels.
Beat the runs and stoppage
Regardless of whether you can't go to the washroom or you can't stop, fiber found in apples can help. Fiber can either haul water out of your colon to keep things moving along when you're moved down, or retain overabundance water from your stool to back your guts off.

Kill bad tempered inside disorder
Bad tempered inside disorder is described by clogging, the runs, and stomach torment and swelling. To control these side effects specialists prescribe avoiding dairy and greasy sustenances. Furthermore, individuals with IBS see great how sustenance can aggravate side effects, however finding out about high-fiber nourishments they can eat (like apples) is critical.

Counteract hemorrhoids
Hemorrhoids are a swollen vein in the butt-centric trench and keeping in mind that not dangerous, these veins can be exceptionally agonizing. They are caused by a lot of weight in the pelvic and rectal regions. A vital part with controlling stoppage, fiber can keep you from stressing excessively while setting off to the restroom and subsequently help reduce hemorrhoids. Fiber, once more, includes medical advantages of apples. A solid stomach related framework implies a sound body.
Control your weight
This is one of the medical advantages of apples a large portion of us will get. Numerous medical issues are related with being overweight, among them coronary illness, stroke, hypertension, type 2 diabetes and rest apnea. To oversee weight and enhance general wellbeing, specialists prescribe an eating regimen rich in fiber. Nourishments high in fiber – like apples – will top you off without costing you an excessive number of calories.
Detoxify your liver
Your liver is in charge of getting these poisons out of your body. Many specialists are distrustful of prevailing fashion detox eats less, saying they can possibly accomplish more mischief than great. Fortunately, a standout amongst other – and least demanding – things you can eat to help detoxify your liver is organic products, similar to apples.

Diminishing your danger of diabetes
Ladies who eat apples – no less than one daily – are 28 for each penny more averse to create compose 2 diabetes than the individuals who don't eat apples. The reason this is a medical advantage of apples is on account of this natural product is stacked with solvent fiber, the way to blunting glucose swings.
 Decrease cholesterol
The dissolvable fiber found in apples ties with fats in the digestive system, which converts into bring down cholesterol levels and a more advantageous you.
Get a more advantageous heart
A broad collection of research has connected high solvent fiber consumption with a slower development of cholesterol-rich plaque in supply routes. The phenolic compound found in apple skins likewise keeps the cholesterol that gets into your framework from setting on your course dividers. At the point when plaque works inside your corridors, it lessens blood stream to your heart, prompting coronary supply route infection
Keep away from Alzheimer's
An investigation on the advantages of apples demonstrates that drinking squeezed apple could keep Alzheimer's away and battle the impacts of maturing on the mind. The mice in the examination that were sustained an apple-upgraded consume less calories indicated more elevated amounts of the neurotransmitter acetylcholine and improved the situation in labyrinth tests than those on a normal eating routine.
Secure against Parkinson's
Research has demonstrated that individuals who eat products of the soil high-fiber nourishments (ahem, apples) might be secured against Parkinson's sickness, a condition portrayed by a breakdown of the cerebrum's dopamine-creating nerve cells. Researchers have connected this to the free radical-battling energy of the cancer prevention agents contained in that.

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